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Abstract #0062

1H-MRS Investigation of IMCL Storage During Resting in Skeletal Muscle: Obese Versus Normal Rats

Zhongwei Qiao1, 2, Peng Cao1, 3, Anna M. Wang1, 2, Victor B. Xie1, 2, Shujuan Fan1, 2, Ed X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China; 3Department of Electrical and Electronic Engineering, The University of Hong Kong,, Hong Kong SAR, China

In this study, we hypothesized that the gradual IMCL storage occurs in skeletal muscle during resting, and such storage at resting state would alter in obesity. Specifically, we investigated the IMCL storage at resting state in obese rats by quantifying the rates of IMCL accumulation using continuous and dynamic 1H-MRS. We demonstrated that dynamic 1H-MRS could quantify the IMCL accumulation at resting state in individual muscles. Our preliminary results revealed that the disorder of lipid metabolism in obesity is associated with not only an increased IMCL content, but also the alterations in the rates of IMCL storage at resting state in both slow-oxidative muscle and fast-oxidative glycolytic muscles.

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Keywords

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