Meeting Banner
Abstract #0055

Can Bound & Mobile Bone Water Be Distinguished by T2* at 9.4T?

MAGNA25Henry H. Ong1, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, Departement of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States

Differentiating bound and mobile bone water (BW) may provide valuable insight in bone health and microarchitecture. Previous reports have used T2* relaxometry to quantify bound and mobile BW at 0.6T and 3T. Here, we investigate the potential to quantify bound and mobile BW with T2* relaxometry at 9.4T. We compared 3-component exponential fits of FIDs from human cortical bone specimens with measurements of BW concentration, porosity, and bound and mobile BW fractions unambiguously quantified by deuterium NMR. The results show that at this field strength the 3-components primarily correlate with collagen protons and mobile BW but not with bound BW

Abstract PDF Presentation Video

Keywords

advantage agree agreement allow allowed amount anterior arise assessment attempt best bone bound brevity coefficients collagen compartment component components concentration consist consistent constraint contributes correlate correlation correlations decay degree describes destructive detection determined deuterium differentiating distinguish distinguished dividing donor donors doublet dwell early exchange exchanged experiment exponential fair field fits fitted fitting foundation fraction fractions function furthermore good harvested henry human identified identify immersed immersion independently insight instr inversion investigate investigated investigation laboratory lateral lipid logarithmic longer magnitude male measured measuring medial medicine meeting mobile model motion nature needed negative normalized oscillations overall particular phys plot pore pores porosity posed positive posterior potential powerful predominantly previous previously problem protons quadrupole quantify radiology readily recently reconstructed recovery renormalized reported represent represents resides restricted roughly saline sample school separate short sides since specimen specimens spectra spectrometer spectrum splitting strong structural suggests summarizes table tibia tool transplant ultra unambiguously understand various view volume water