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Abstract #4535

Comparison of Carotid Plaque Characteristics Between Japanese and Midwest American Caucasian Patients with Coronary Artery Disease: A 3.0T MRI Study.

Hideki Ota1, J. Kevin DeMarco2, Minako Wakayama3, David C. Zhu2, Kei Takase1, Shoki Takahashi1

1Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan; 2Radiology, Michigan State University, East Lansing, MI, United States; 3Cardiology, Sendai Red Cross Hospital, Sendai, Miyagi, Japan

The purpose of this study was to compare carotid plaque characteristics in Japanese (Asian) and Midwest American (Caucasian) patients with advanced atherosclerosis. Twenty-two Japanese and 32 American men with asymptomatic >50% carotid stenosis and history of coronary artery disease underwent multi-contrast carotid MR imaging. After adjusting for baseline demographic characteristics as possible confounders, Japanese patients more commonly had complicated AHA-type VI plaque, hemorrhage and larger necrotic core than Americans. The present results indicate that the development of carotid atherosclerosis appears different between the two populations with advanced atherosclerosis.

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Keywords

acquisition adjusted advanced among analyses angiography applied artery association associations asymptomatic atherosclerosis audience axial backgrounds bifurcation blinded body calcification calcified cardiovascular carotid characteristics clinical component composition computed consensus contrast core coronary criteria cross death degree demographic diabetes diagnostic disease documented east either enhanced established ethnic ethnics evaluated event events extent features fifty findings five flight future geographic gradient health heart hemorrhage highly histology history hospital in vivo included inclusion index indicated infusion international interpreted intravenous investigate japan journal larger lifestyle linear logistic magnetization major male management mass materials measure measured median medical mesa mild morphology mortality myocardial necrotic nodules nonfatal north obese others outpatients participated patient patients plaque population populations positively potential prepared presence prevalence prevalent previous published quantitative racial radiologists radiology rapid recorded regression reports reviewers risk screening severe significantly smoking stroke studies subject subjects surface target thrombus transformations trend trials type underwent validated various vascular vessel volume wall weightings year yuan