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Abstract #4531

Gadofosveset Optimization for Self-Navigated Coronary MR Angiography

Mark A. Ahlman1, Scott Penzak2, Fabio Raman1, Jianing Pang3, Songtao Liu1, Debiao Li3, David A. Bluemke1

1Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States; 2Pharmacy, National Institutes of Health, Bethesda, MD, United States; 3Bioengineering, Cedars-Sianai Medical Center, Los Angeles, CA, United States

We proposed and validated a mathematically derived injection protocol for an intravascular contrast agent (Gadofosveset) that results in near constant blood T1 time over 5-6 minutes. Such an injection protocol should be idea for a 3D radial coronary MRA sequence with self-navigation. Using this model, we give evidence for proof-of-concept of the clinical applicability of our injection technique in humans.

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Keywords

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