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Abstract #4447

4D MR Pressure Difference Mapping: Comparison with Echocardiography and Invasive Catheter Measurements

Jelena Bock1, Julia Geiger1, Raoul Arnold2, Daniel Hirtler1, Hans Burkhardt1, Michael Markl3

1University of Freiburg, Freiburg, Germany; 2University of Heidelberg, Heidelberg, Germany; 3Northwestern University, Chicago, IL, United States

Pressure gradients are an important clinical marker for the severity of cardiovascular disease such as aortic valve stenosis or aortic coarctation. It was the aim of this study to evaluate the potential of an optimized data analysis strategy based on 4D flow MRI for the assessment of aortic 3D pressure difference maps compared to the gold standard invasive catheter measurements in patients with aortic coarctation. Differences between MRI, echocardiography and catheter measurements demonstrate the potential of MRI to non-invasively determine pressure gradients in aortic coarctation and indicate the importance of dynamic aortic boundary conditions for accurate pressure difference estimation.

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Keywords

academic accurate additionally advanced angiography aorta aortic applications approval artery ascending assessment blood bock boundaries boundary branch calculation cardiac cardiovascular care catheter circulation clinical cluster committee conditions controlled coverage covering derived descending determine determined deviation directional disease distribution dynamic edge entire equation estimation ethics evaluate even examined excellence except explain feature female five flow foundation frames full gated gold gradient gradients grant grants idealized illustration in vivo include included indicate informed initiative inside intervals invasive iteratively knowledge known limitations local locations lumen magnitude manually mapping maps marker maximal measure measured medicine memorial midway modalities modeling moderate months moreover northwestern optimized overestimated overestimation part patient patients peak phantoms positioned potential pressure prior program proving pulmonary regional represent reproducibility resolution resolved respiration schematic segmentation segmentations segmented severity simplified software spatial static stokes strategies strategy studies subjects summarized supra system systolic table temporal thoracic translational validation valve variable vascular velocities velocity versus vessel visualization volumetric years