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Abstract #4437

Hemodynamic Forces in the Progression of Intracranial Aneurysm Change as Assessed Using MR-Based Methods

David A. Saloner1, Evan Kao2, Gabriel Acevedo-Bolton2, Andrew Lee2, Petter Dyverfeldt2, Vitaliy L. Rayz2

1Radiology and Biomedical Imaging, VA/UCSF, San Francisco, CA, United States; 2Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

MR methods can be used to assess changes in aneurysm morphology over time. In addition vascular geometry and inlet flow conditions that are needed for Computational Fluid Dynamics can be determined using MRA and MR velocimetry. These methods were used in the evaluation of 78 aneurysms that were followed over time. CFD predictions indicate that there is an increased rate of growth in aneurysms where a large fraction of the aneurysm surface is exposed to low wall shear stress.

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Keywords

acceleration accurate agreement analyses aneurysm aneurysms approved arteries assess assessed biomedical boundary calculations cerebral circulation clinicians complex computational computed conditions conducted consistent constructed contrast controversial determine determining dimensional disease drive dynamics elsewhere enhanced error evaluate even evolution exact excellent experimental experimentally exposed features feeding fiducial field fields flow fluid forces fraction free frequency full furthermore geometry global great greater grew grow growth helping highly histograms identify identifying importance important imposed indicate indicated indicates inlet internal interval intervals larger layer lead link long maintained markers matched measured models months morphology others parallel patient patients petter physiological population predicted predictions presentation progress progression properties protocol radiology rapid rapidly recirculating regional registered related remain remained replica reported reports representative requiring resolution risk segment serial session shear significantly slices slow stable stress studied studies subjects substantially surface thought thrombus transverse untreated validate vascular velocity vessel vessels volume wall whether whose year