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Abstract #4333

Combined Pre- And Intra-Operative fMRI for Neurosurgical Guidance: Data Alignment and Bayesian Analysis.

Joerg Magerkurth1, Laura Mancini1, William Penny2, Guillaume Flandin2, John Ashburner2, Caroline Micallef1, Enrico De Vita1, Tarek A. Yousry1, John Thornton1, Nikolaus Weiskopf2

1Department for Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 2Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom

Intra-operative fMRI combined with pre-surgical fMRI planning could provide crucial information to guide neurosurgery. The intra-operative (1.5T) MR scanner at our institution presents lower signal-to-noise and contrast-to-noise ratios and significantly larger distortions than the 3T MR scanner used pre-operatively. We present a pre-processing and Bayesian analysis method for pre- and intra-operative fMRI. While classical inference identifies only activated area, the Bayesian approach labels three areas: activated, non-activated, and areas where the data do not allow for a robust classification. The method was tested on 10 healthy volunteers in a passive movement paradigm, which could also be used under anesthesia.

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Keywords

accurate achieved acquisition activated activation active aligning alignment anatomical applicable attribute audience biomedical blocks bold brain calculation careful challenges channel classified clear clinical clinically coil coils combined complex comprehensive contrast corrected correction cortex covering deactivation decision decrease defined defining design determine developed difficult distortion distortions distribution duration enclosed environment except expected explicit extended fall field final fingers flexed functional future going gradient green guide hand head healthy house independently inference inform inherent instrumental interpreting intra intrinsically john kingdom labeled laura limitation limitations linear linearity local localized made major manufacturer maps match material medicine motor necessary necessitating neither neuroanatomy neurology neurosurgery noise operative operator paradigm particularly passive patient penny physicist physiological planning poses posterior probability processed processing promise providing radiologist realigned reduced reflected registered related relevant repair requires revealed robust robustly scaled scanner scanners scanning since spatial statistics strengths subject subjects supplementary surface surgical susceptibility system threshold trio trust useful usefulness vita