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Abstract #4315

Real-Time Monitoring for Systematic Investigation of Catheter Design and Infusion Protocol Effect on CED Performance

Benjamin Grabow1, Raghu Raghavan2, Martin Brady2, Ken Kubota3, Chris Ross4, Samuel A. Hurley5, Ethan K. Brodsky1, James Raschke3, Andrew L. Alexander6, Walter F. Block5

1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States; 2Therataxis LLC, Baltimore, MD, United States; 3Kinetics Foundation, Los Altos, CA, United States; 4Engineering Resources Group, Inc, Hialeah, FL, United States; 5Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 6Medical Physics, University of Wisconsin, Madison, WI, United States

Rapid 2D monitoring and real-time MR guidance of device insertion is used to enable systematic investigation of catheter design and infusion protocol effects on convection-enhanced delivery infusion performance.

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Keywords

accurately acquisition adding addition agents alignment allowing alters amounts animals approximately attempt benefit biomedical brain cancer catheter catheters characteristics cloud combination conducted conducting conference consisted constant consuming control controlled convection cost delivered delivery design desired detection developed development device disparate distribution drug enabled enables engineering enhanced ensemble escape eventual every experiment experimental extends exterior final flow foundation full fused gradually gray guidance height house human hypothesis identification immediately in vivo inclusion influence infused infusion infusions initial insight investigates investigation journal leakage length localized loss manipulation many minutes mitigate model monitoring morphology neurosurgery novel occurs ongoing operator operators overall overhead people performance personnel physics pictured predict previously procedure procedures produces progression prospective protocols providing quantitative question radially radius ramped ramping rapid real reflux requirements resolved resources roughly sciences silica software specialist speed spherical starting stepped system systematic target targeting temporal today tract trajectory treatment ultimate understanding undertake unwanted upward variable variables visible volume volumetric