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Abstract #4313

High-Resolution MRI of Temporal Evolution of Thermal Ablation Lesions

Benu Sethi1, Andriy Shmatukha1, Mohammed Shurrab2, Jennifer Barry3, Eugene Crystal2

1Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 2Arrhythmia Services, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 3Sunnybrook Research Institute, Sunnybrook Research Institute, Toronto, Ontario, Canada

3D High-Resolution MRI is used for analyzing the internal compositions of thermal ablation lesions and their evolution after the ablation. The usefulness of different MRI techniques and their correlation to histology at different post-ablation periods is discussed. T1w MRI is shown to discriminate between coagulation necrosis and hemorrhage in acute lesions. T2w MRI is demonstrated to depict the contraction band necrosis rim as accurately as delayed enhancement at a certain period after ablation, when the ablation lesion borders become well defined, leading to satisfactory ablation lesions border delineation without Gd injection.

Keywords

ablation ablations accompanied accurately acquisition acute agent aiming almost animals another appeared appropriate around arrhythmia arrhythmias attributed audience band became become borders bright broader cardiac cells challenging clinical coagulation comprised consisted contraction contrast core cores correlation correspond counterparts created damage dark darkest defined dehydrated depth diffused digital distant drug early especially estimator evolution examination except exist failing fuzzy golden good half healed healing health heart histological histology hyper identify immediately improve inflammatory initial injection intense intensity lesion lesions looked mapping middle muscle muscles narrow necrosis observations ones outcome outside overlap post predictor preserved previous previously procedures prominent properly quantification rabbit rabbits receive reflected relatively reliable reported represent resistant resolution rest rims sacrifice sacrificed samples scanned sciences serve services several severe sharp sharpness slices smaller space spacing spatial stage strategies substitute suffering sufficiently surface surrounded surrounding survived target temporal thermal thick thin tissue train treatment types typically unclear wide widening zone zones