Meeting Banner
Abstract #4295

Non-Invasive Temperature Mapping Using Temperature-Responsive Water Saturation Shift Referencing (T-WASSR) MRI

Guanshu Liu1, 2, Qin Qin2, Kannie W.Y. Chan3, 4, Jeff W.M. Bulte3, 4, Michael T. McMahon1, 2, Peter C.M. van Zijl1, 2, Assaf A. Gilad3, 4

1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; 4Cellular Imaging Section, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Monitoring of temperature changes in deep-seated tissues is a necessity during the course of cancer thermotherapy. Among currently available MR temperature mapping methods, water proton resonance frequency (PRF) imaging is the most widely used technology, but it is often hampered by interference from lipid signals. We developed a new approach for assessing the water PRF through direct water saturation to overcome problems with fat resonance interference. Compared to phase mapping, the currently most popular PRF measurement method, the temperature-responsive water saturation shift referencing (T-WASSR) method was demonstrated with an improved performance in fat-containing tissue.

Abstract PDF Presentation Video

Keywords

able absolute acquisition adapted adding allows alternative application applied assess assessing audience bars bath blue bore bottom brain cancer capability capable cell cellular cheese chemical clearly coefficient coil comparing connected consequently consistent containing content contrast control correction correlated correlation cycling detecting determine determined determining develop developing deviation direct directly drawn elevated engineering equipped error especially example fast feasibility findings fitting frequencies frequency functional good grants improved in vivo inaccurate indicate indicating induced institute intra invasive johns lattice legs lipid localized manually mapping maps matrix measured measuring media medicine methodology middle modified monitoring moreover mouse needing nominal noninvasive offsets oncologists panel peter phantom piece plastic press previously principle produced proton protons pulse radiology rare ready receiving referencing reliably reported researchers resolution respect respectively response responsive robustness sample saturation school science section spatial spectra spectrum spin steady strength suitable sweeping swept system target temperature temperatures temporal thermocouple thermometry tissues vertical vial vitro water wave weak