Meeting Banner
Abstract #4277

3D Mapping of T2* and B0 Inhomogeneities for Water/Fat Separation

Abraam S. Soliman1, 2, Jing Yuan2, Terry M. Peters1, 2, Charles A. McKenzie1, 3

1Biomedical Engineering, University of Western Ontario, London, Ontario, Canada; 2Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 3Medical Biophysics, University of Western Ontario, London, Ontario, Canada

Several confounding factors can compromise the ability of MRI to accurately quantify fat, particularly B0 inhomogeneities and T2* decay. Recently, a labeling approach has been proposed to estimate B0 field variations in fat/water separation and was shown to outperform the widely-used region growing method. In this work, we extend this technique to 3D as well as integrate pixel-by-pixel calculation of T2* decay, necessary for accurate fat quantification. We demonstrate our approach on data for healthy volunteers and NAFLD patients.

Abstract PDF Presentation Video

Keywords

ability account accurate acquisition actual advantage allows amplitude anatomies appear apply approximate array audience avoid avoiding axially bandwidth biomedical biophysics calibrated called certain clearly coarse coil commonly components consider considered considering cost datasets decay denotes derived described discovery divided efficient embedded employed employing enforcing engineering entire equation estimation extend extended extending extremities fact field final fraction frequency function growing healthy help hindered ideal independent inferior inhomogeneities initial integrated inter intuitively iron iterative labeled labeling laboratories literature liver local mapping maps matrix medical might model moreover necessary nevertheless offset overload patient patients peak peaks peters pixel presence prior problem process property proposed providing quantification quantify reconstruction reeder relying researchers respective role separate separation severely simultaneously slice slices smooth smoothly smoothness spatially spectrum stage steps still subject subsequently successful successfully superior swap swaps take takes taking target targets terry throughout variation variations vary varying view volume volumes volumetric volunteers water western words yuan