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Abstract #4222

Intervertebral Disc CEST Imaging with Improved Reliability Using Reduced-FOV TSE

Qi Liu1, 2, Ning Jin3, Zhaoyang Fan1, Yutaka Natsuaki4, Wafa Tawackoli1, Dan Gazit1, Gadi Pelled1, Debiao Li1, 5

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Biomedical Engineering, Northwestern University, Chicago, IL, United States; 3Siemens Medical Solutions, Columbus, OH, United States; 4Siemens Healthcare, Los Angeles, CA, United States; 5University of California, Los Angeles, los angeles, CA, United States

A reduced-field-of-view (rFOV) TSE method is used to reliably measure IVD gagCEST signal in vivo by reducing bowel movement artifacts on a 3.0T clinical scanner. The proposed method is verified by a phantom study, and is compared with the conventional full-FOV CEST technique on nine volunteers.

Keywords

absolute accurate achieved acquisition acquisitions applicability applying approved artifacts assessed back bandwidth biochemical biomedical board body bone bowel buffered burden cedars chemical clinical close closely coil composition concentration concentrations consent containing correct corrected curve cycle decreased degeneration differentiating disc disease distributed doors drawn duty encoding engineering evenly excitation explained fail female field frequency full gradients healthy identify implying improved in vivo indicates informed inhomogeneity insight inspection institutional joint lasting lead limit little loss male measure measuring medical might minimizing movement nine nonlinearity northwestern nucleus offsets opens pain phantom phosphate physiological pixel position preparation prepared prevalence propose proposed protons pulse pulses quantification quantify quantitative random recently recruited reduced reducing refocusing regarded relationship reliability reliable repeated repetitions resolution respectively review saline samples saturation scanner sensitive severe sigma sign significantly slice smaller solution solutions space studies subsequently suffers sulphate system titrated train transfer transverse turbo twice typical variation various verified verify view volunteer volunteers wide zone