Meeting Banner
Abstract #4181

Evaluation of Effective Regions in Deep Brain Stimulation Using MR-Based Current Density Imaging (MRCDI): In Vivo Canine Brain Study

Munish Chauhan1, Saurav ZK Sajib1, Woo Chul Jeong1, Hyung Joong Kim1, Oh In Kwon2, Eung Je Woo1

1Kyung Hee University, Yongin, Gyeonggi, Korea; 2Konkuk University, Seoul, Korea

Deep brain stimulation (DBS) is widely used technique for the treatment of various movement disorders such as dystonia, tremor, and Parkinson disease. Due to the inherent limitations of the imaging modalities, physicians cannot diagnosis the exact response of the brain tissues during the stimulation. Recent MR-based current density imaging (MRCDI) technique enables us to estimate the current density distribution using one component of the measured magnetic flux density data. Applying MRCDI technique to DBS, we can predict the current pathway and volume tissue activation which could be useful information for adjusting the electrode parameters and neuronal surgical planning.

Abstract PDF Presentation Video

Keywords

absolute activation acts amplitude anodic applications applied assessment audience avoiding better bipolar boundary brain canine clinical comparing component concentric conductive conductivity configuration configurations contains damage dark deep defected defined density described designed determined diagnosis distribution domain effective electrode electromagnetic equation estimating estimation evaluate evaluation excitation experiment fact finding flow flux geometry gradient ground head helpful hence implanted in vivo included indicates induces injection inside internal limited local magnitude manually mapping marked matrix measured might minimize mode mono moreover neighboring neuronal noise often operation optimal outer park part path pathway pathways people polar poor position potential predicting presence prognosis projected property proton pulse quantitative reconstruction recoverable recovered regional relationship represent respective respectively segmented select short side sink sinus skull slice slices source spread stem stimulation stimulator suggest surgical target therapeutic tissue tool useful voltage volume whole widely width