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Abstract #4123

Amide Proton Transfer (APT) Imaging of Uterine Tumors: A Preliminary Clinical Study

Yukihisa Takayama1, Akihiro Nishie2, Osamu Togao1, Yoshiki Asayama2, Yasuhiro Ushijima2, Nobuhiro Fujita2, Takashi Yoshiura2, Makoto Obara3, Jochen Keupp4, Hiroshi Honda2

1Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 2Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 3Philips Electronics Japan, Tokyo, Japan; 4Philips Technologie GmbH Forschungslaboratorien, Hamburg, Germany

In this study, we investigated the feasibility of CEST imaging for the assessment of uterine tumors; endometrial carcinoma (EMCA) and squamous cell carcinoma (SCC). Our results showed that the spectra of MTRasym of EMCA were significantly higher than those of SCC at from 2.2 ppm to 3.7 ppm and from 4.8 ppm to 5.1 ppm. In addition, amide proton transfer (APT) map showed that APT ratio of EMCA was significantly higher than that of SCC. CEST imaging of uterine tumor may be feasible in clinical practice because this imaging can provide molecular information such as histological characteristics.

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Keywords

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