Meeting Banner
Abstract #4105

Normalized T1 Relaxation Time Mapping for Improved Lung Imaging in Cystic Fibrosis Patients

Lan Lu1, Elliott C. Dasenbrook2, David Weaver2, Peter M. Jakob3, Mitchell L. Drumm2, Michael W. Konstan2, Chris A. Flask1

1Department of Radiology, Case Western Reserve University, Cleveland, OH, United States; 2Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States; 3Department of Physics, University of Wurzburg, Wurzburg, Germany

We have developed a method to normalize lung T1 relaxation time assessments as an biomarker for early-stage lung disease in cystic fibrosis (CF) patients. The T1 relaxation times were normalized by the mean T1 values in the central lung regions to limit the effects of anatomic variation. Normalized T1 assessments were obtained for six CF patients and five healthy controls. The normalized T1 relaxation time assessments showed reduced variation in comparison to conventional T1 relaxation times and differentiated early-stage CF patients from healthy controls while gold-standard pulmonary function tests did not suggesting greater sensitivity of this new MRI method.

Abstract PDF Presentation Video

Keywords

able absolute accurate acquiring acquisition adult advantage agents airways ambient anatomic applied arrows assessed assessment black breathing central chronic clearly clinical contrast control controls correlates correlation cystic decrease decreased despite detecting determine developed differentiate disease diseases dividing early eliminates enhanced equipment exact exhibited extend extremely fibrosis five flask focal function generally gold greatly healthy ideally identifying importantly improved infant ionizing limit limitation linear locker look lung making mapping maps measures mechanism middle much need needed normalize normalized overlaid oxygen paramagnetic patient patients pediatric pediatrics peter physics predicted previously problematic pulmonary quantification quantitative radiation radiology rapid reduced reduces regional registration regression reliable representative requirement requires reserve room screening sedated sensitive significantly simplicity simplified slice stage student studies subject subjects succession suggest suited supplemental together tool translational upper utility variation ventilation volunteer volunteers weaver western