Meeting Banner
Abstract #4089

Evaluation of a Screening Dixon Sequence for Detecting Presence of Iron/ Fat in Patients with Chronic Liver Disease

Liana Rocha1, Caroline Amoedo2, Fernanda Mago2, Marcio Reis2, Ralph Strecker3, Xiadong Zhong4, Stephan A.R. Kannengiesser5, Ronaldo Baroni2

1Imaging Department , Hospital Israelita Albert Einstein, So Paulo, Brazil; 2Imaging Department, Hospital Israelita Albert Einstein, So Paulo, Brazil; 3Healthcare MR, Siemens Ltda, So Paulo, Brazil; 4MR R&D Collaborations, Siemens Healthcare , Atlanta, Geogia, United States; 5Healthcare MR, Siemens, Erlangen, Bavaria, Germany

Magnetic resonance imaging (MRI) has been recognized as a non-invasive method for detection and quantification of fat and iron deposition in the liver. Recently, a two-point automated dual-ratio Dixon discrimination technique with automatic liver segmentation, dubbed screening Dixon (SD), has emerged as a potential method for screening and discrimination of fat and iron signals. The purpose of this study was to evaluate the accuracy of the SD sequence with automatic estimation of fat/ iron contents in a population of chronic liver disease (presence of siderotic lesions and steatosis) and compare them with the results of our routine quantitative sequences as the reference standards: GRE multi-echo for Iron deposition and 3-echo GRE Dixon for fat. 70 abdominal MRI performed at 1,5T were compared. Considering only the presence (altered) or absence (normal) of disease, SD demonstrates 100%, 86.96% and 91.43% for sensitivity, specificity and accuracy, resp. When we considered only presence or absence of FD, SD was more specific (90.38%) than sensitive (50%), with accuracy of 80%. When we considered only the presence or absence of ID, SD was 100% sensitive, with specificity of 82.76% and accuracy of 85.71%. Although the type of deposition is not perfectly discriminated, SD is an accurate method for detecting presence or absence of fat/iron deposition in the liver, being adequate as a screening technique in general MRI abdominal studies.

Abstract PDF Presentation Video

Keywords

abdominal absence according accuracy accurate addition adequate aimed altered although among approved artifacts automated automatic believe blue board body capable categorization categorizations categorized chronic classes classified coil color column concordance consequence considered considering contents corp correction correctness deposition detect detecting detection development diffuse disagreement discordant discriminated discrimination disease drawn dual echoes efficient electric emerged enrolled error estimation evaluate evaluated example exams excluded expect expected final fitted future general generated hepatic highly identifying inadequate included institutional iron kappa lead limitation liver lobe local maps materials matrix measure measured middle misdiagnosed missed nodules none opposed overall overlaid overload patient patients percentage perfectly performance poor population presence protocol qualitatively quantification quantitative radiologist radiology recognized recommendation recommendations reconstruction related relevant report respectively resultant retrospectively review saturated scanner screening segmentation sensitive sensitivity serve short since specificity spine studied studies suggest suggestions table targeting technical totally transplantation undergone unnecessary upper validated vibe waiting wood workstation wrong yellow