Meeting Banner
Abstract #4084

Free-Breathing Dynamic Contrast Enhanced Compressed-Sensing Imaging for Reliable Estimation of Liver Perfusion

Hersh Chandarana1, Kai Tobias Block1, Henry Rusinek1, Matthew B. Greenberg1, Li Feng2, Daniel K. Sodickson1, Ricardo Otazo1

1Radiology; Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States; 2Radiology; Center for Biomedical Imaging, New York University Langone Medical Center, New York, NY, United States

Studies have shown the utility of perfusion weighted MR imaging in diagnosis of liver fibrosis and assessment of portal hypertension. Here we performed free-breathing high spatial and temporal resolution liver imaging with compressed sensing technique called GRASP. GRASP data was reconstructed with temporal resolution of 3 seconds and processed with dual-input single compartment model to generate perfusion metrics, which were significantly different in cirrhotics compared to healthy subjects. Advantages over Cartesian scheme are higher resolution, motion robustness eliminating need for labor-intensive registration, and generating dynamic perfusion data from routine clinical exam, hence eliminating need for additional contrast dose or acquisition time.

Abstract PDF Presentation Video

Keywords

abdominal accelerated acquisition acquisitions adjacent advanced advantages although anatomic aorta apparent approved approximately arterial assessment audience biomedical blinded block breathing called cirrhosis cirrhotics clinical compartment compliant compressed concordant continuously contrast converted correlations coverage covering curves decreased degree described diagnosis discriminate discriminating distribution dose dual dynamic eliminating enhanced entire estimation evaluating exam expense exploited extended feasibility fibrosis findings flush focus fraction free future gadolinium generate generated golden gradient grant grasp healthy help heterogeneous hypertension implementation include initiated injected injection input intensity intravenous invest labor liver lobe male measure measuring medical metrics model modeling motion necessary need novel parallel patient patients perfusion placed portal press previously propagated prospective proven published radial radiologists radiology reach reader reconstructed reconstruction reduce registration relatively resolution robustness saline sampling scheme schemes science sensing series several significance simultaneously slice slices spatial spokes sponsor stack standalone studies subjects table target temporal trajectory transit undergoing uniform utility valuable various vein whole