MRI-Based Measurement of the Pancreatic Extracellular Volume Detects Immune Cell Infiltration in a Mouse Model of Type 1 Diabetes

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accordingly acquisition acute administration adoptive affects agent aldehyde although animal animals applicable approved approximately around association award axial blood care cavity cell cells cellular circulation clinical clinically committee common confirmed contrast control course critical curves days decreased demonstrating destroy destruction detect detected detection detects development diabetes diffuse disease disorder dosage duration early equilibrium establish established example extracellular fibrosis form funding furthermore glucose gold heart highly histology hour humans hypothesized identify immediately immune infiltrate infiltration inflammatory infusion injected injecting injection institutional insulin intensity intravenous invaded invading invest investigated lack least loss maintaining mapping maps mass matched measured metabolic mice million minutes model monitored mouse occurs overt pancreas pancreatic persists pool positive potential potentially predictive prior progression readily recovery reduction rejection remained resolution revealed risk roles sacrificed satisfactory science service significantly specialized specifically stain system tail therapeutic took transfer transferred translatable treatments type typical underwent useful vehicle ventricular volume wherein whether white window