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Abstract #4041

Environmental Stimulation During Development Modulates Individual Behavioural and Neurochemical Responses to Cannabinoid Agonists in Mice: A 1H MRS Study

Luisa Altabella1, Chiara Ceci1, Simone Macri'1, Rossella Canese2, Giovanni Laviola1

1Cell Biology and Neuroscience, Istituto Superiore di Sanita', Rome, Italy; 2Cell Biology and Neuroscience, Istituto Superiore di Sanit, Rome, Italy

Adverse environmental conditions may increase the vulnerability towards the effects of the consumption of psychoactive drugs. Conversely, stimulating environmental conditions may exert a protective or compensatory role. Hypothalamic-pituitary-adrenal (HPA) system and the endocannabinoid system (ECS) interact to modulate the expression of emotions. An adolescence treatment in mice with endocannabinoid JWH-018 is studied in adulthood with 1HMRS in combination with a neonatal corticosterone administration (LC) or environmentally enriched (EE) housing after weaning. Major finding indicates that both stresses (LC or EE) can revert the JWH-018 effects in several metabolite concentrations in PFC and Hip.

Keywords

according additive administered administration adolescence adolescent adrenal adulthood adverse alone alterations analyses animals anxiety behavioral beside biology biomedical body brain cell childhood clinical coil collected combined compensatory concentrations conditions confirmed consecutive consequences consider consumption contrasts contribute conversely cortex council course days decreases dependent detected development disturbances dose drugs emotion emotional emotions enriched enrichment environmental environmentally environments ethanol exert exerting experimental exposed exposure expression fast favor find fitting glutamate grant head housed hypothesis includes independent indicate individual interaction interactions long mainly matrix metabolic metabolite metabolites mice ministers moderate modulate modulates mouse multivariate neonatal occurred onset operating pharmacological physical pituitary policies pool postnatal presidency press program protective protocol quantification quantitative rapid rearing receiver reduced regarding resilience respect response responses revert reverts role saline short significantly slices social spectra stimulating stimulation stimuli stress studies supplemented support surface system systems temperature term throughout towards transmitter treated treatment trend variables variance vehicle volume vulnerability water weaning