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Abstract #4032

Editing Cancer Biomarker, 2-Hydroxyglutarate, with a Novel Proton Magnetic Resonance Spectroscopy

Napapon Sailasuta1, Jackson Hamilton2, Edward F. Jackson2, Pratip Bhattacharya2, William Perman3, Niki Zacharias2, Brian D. Ross1, Ralph Noeske4

1HMRI, Pasadena, CA, United States; 2MD Anderson Cancer Center, University of Texas, Houston, TX, United States; 3Radiology, Saint Louis University, St. Louis, MO, United States; 4GEHealthcare, Berlin, Germany, Germany

We introduce a novel approach to measure 2-hydroxyglutarate,a cancer biomarker, using a oneshot simple proton MRS method suitable for human scan.

Keywords

ability acquisition activation acute added approximation assess author background behave brain brains broad cancer candidate cell cells chemical classifications clearly common components concentration constants coupling currently cycle description determine diagnosis difficult direct diseased edited editing embedded ending enzymes examined field financial form foundation gamma give glutamate glycine goal grade great hard holds human important increasing intermediate internal introduce invasive leukemia library liquid long lymphoma marker medicine metabolite metabolize mixture modality mutated mutations nature neuronal neurotransmitter novel occurrence optimization overlapping parsons patients potential press probe progress project proton proven pseudo published pulse quality quantifiable quantify radiology reflect relationship reliable resolved saint scanner scanning secondary separated sets several short simple simulation singlet smith software solution solutions spectra spectral spectroscopy spin starting strong studies subjects suitable support systems thank timing tumor underlying unobstructed vitro