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Abstract #4016

In Vivo 3D 31P MR Spectroscopic Imaging of Human Brain Tumors Growing Orthotopic in the Mouse

Andor Veltien1, Morteza Esmaeili2, Bob C. Hamans1, Anneke C. Navis3, Tone Frost Bathen2, Ingrid Susann Gribbestad4, William P. Leenders3, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 3Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 4Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

By In vivo 31P MRS it is possible to observe the resolved signals of some key lipid and high energy metabolites and therefore this is an important technique to study tumor biology, to evaluate treatments and to identify diagnostic biomarkers. For studies of brain tumors it is also relevant to be able to perform localized 31P MRS of orthotopically growing tumors in the brain of mouse. In this work we demonstrate that 31P MRSI of high quality can be obtained of 4 different human glioma growing in the mouse brain.

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Keywords

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