Meeting Banner
Abstract #4009

In Vivo 3D Spectroscopic Imaging of 19F Compounds Using Backprojection

Muhammed Yildirim1, 2, Raquel Daz-Lpez3, Klaas Nicolay2, Rolf Lamerichs3, 4

1MR Development, Advanced Diagnostic Imaging, Philips Healthcare, Best, Netherlands; 2Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands; 3Philips Research, Eindhoven, Netherlands; 4Academic Medical Center, Amsterdam, Netherlands

Combination of Fluorine ultrafast Turbo Spectroscopic Imaging (F-uTSI) sequence with backprojection acquisition and reconstruction allows 3D fluorine hot-spot images to be obtained in shorter times and with higher sensitivity in comparison to all phase encoded 3D acquisition. The technique has been used to image orally administered perfluoro octyl bromide (PFOB) containing polymeric microcapsules in the gastro-intestinal tract of black mice. In vivo results revealed a scan time reduction of 40% and SNR gain up to 75%, with excellent spatial resolution of 1 mm along all imaging axes.

Abstract PDF Presentation Video

Keywords

academic accordance achieved acknowledgment acquisition advanced agents allows alternative anatomic anatomical anesthesia angular anti antibody applying approximately artifact atropine axes bandwidth best biomedical black body bowel bromide capability capsules chemical compounds conducted consist contrast converted core coronal dataset datasets decode detail development diagnostic dual eliminates emulsification emulsified emulsion emulsions encapsulating encoded equipped ethical evaporation excellent fast fluorine form free fused geometric gradient guidelines hours human in vivo independent infusion injection integration intra introduce inverse localization maintain mater medical medicine mice micro minutes modified molecular naturally need novel occur offers orally overlays peritoneal polymeric possibility prepared prior process projection projections proves qualitatively quality rabbits radial radon recorded reducing regulatory repetition required resolution resolutions respectively response sacrificing sampling scanner scanning sensitivity sets shorter since slice solution solvent space spacing spatial specificity spectral spectroscopic spot step stoker strong structures successful targeted technology timing towards trains trajectories transform translational transverse tumor tumors turbo ultrafast varying volumetric whole