Meeting Banner
Abstract #4005

A Multiparametric MR Approach for Comparative Assessment of Neurometabolites and Brain Microstructural Changes in Mice Model for Cranial and Whole Body Radiation Exposure

Poonam Rana1, Mamta Gupta1, Richa Trivedi1, B.S.Hemanth Kumar1, Ravi Soni2, Ram Kishore Singh Rathore3, Rajendra P. Tripathi1, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 3Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India

Understanding the early differential response of brain during radiation exposure is significant for better injury management during accidental or intentional exposure to ionizing radiation. The present study based on DTI and 1H MRS was conducted to investigate the early microstructural and metabolic profiles in mouse brain following whole body radiation or cranial radiation exposure. The results exhibited more DTI based FA and MRS based metabolic changes in whole body radiation group compared to cranial irradiation group. This disparity in response could be due to involvement of systemic inflammatory response of central nervous system in case of whole body irradiation only.

Abstract PDF

Keywords

abnormalities absent accident accidental account additionally allied among animals anisotropy antioxidant array assessment believed biosciences body brain cancer cascades central coded coil combined comparative contributory controls cope corpus cortex course cranial cranium decrease decreased development differential diffusion diffusivity disturbances documented dose early either encoding evaluate exposed exposure field findings focal fractional fully generation glutamate gradient help helpful hypo hypothalamus hypothesize identify in vivo induced inflammatory initiated injury institute intensities intentional interpreted involvement ionizing irradiated irradiation lesions linear macrophage male maps markers materials mathematics measured medicine metabolic metabolites mice might model monitoring moreover motor mouse neurosurgery notable nuclear obvious opportunity osmotic oxidant oxidative partial plus position post powerful presumed processed proliferation proton quantifiable radiation reactive receive reduced reflect regulated repetition required resolved respectively respond response responses sciences sensory sham since software spectra spectroscopy stage stages statistical strain studies system table taken technology temporal thalamus together transmit type understanding unit valuable variance weeks whole yang