Meeting Banner
Abstract #3972

J-Difference Editing of GABA: Simulated and Experimental Multiplet Patterns

Richard Anthony Edward Edden1, 2, Jamie Near3, C. John Evans4, Nicolaas A. J. Puts, 25, Peter B. Barker1, 2

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada; 4CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom; 5Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

In this abstract, we investigate factors that influence the multiplet pattern observed in J-difference editing of GABA. Density matrix simulations were applied to investigate the shape of the 3 ppm multiplet as a function of the editing sequences slice-selective refocusing pulse properties, in particular bandwidth, transition width, and flip angle.

Abstract PDF Presentation Video

Keywords

absence acquisition addition additional amplitude appearance applied applying array artifacts assumed asymmetric audience bandwidth barker behavior brain calculation caused central clinical complicated conditions constants contribution coupling decreases density dependent depends detecting distinguish doublet edited editing efficiency even evolution excitation expectation expected experiment experimental extent field firstly form full function functional functions global health house ideal illustrate implementation in vivo increasing influence institute intensities intensity investigate investigation john johns largely like magnetically making marker match matrix medicine mega mental methylene metric modulated motivated multiplet namely near neurotransmitter numerical orange outer particularly patterns peak peaks peter phantom positions precession predicted presence press profile pseudo psychology pulse pulses quality radiological radiology recognize rectangular reduced reduction refocusing relatively resolved rotation rotations routines scanners school science secondly selective several similarly simple simulated simulations slice spatial spatially spectra spectral spectrum spin spins splitting strong structure subtraction system systems taken target transition true unaffected variability variable view wales whole zone