Meeting Banner
Abstract #3963

Short TE Whole Brain MRSI with High-Bandwidth Adiabatic SLR Refocusing and Echo Planar Readout

Meng Gu1, Priti Balchandani1, 2, Sulaiman Sheriff3, Mohammad Sabati3, Daniel Spielman1, Andrew Maudsley3

1Radiology, Stanford University, Stanford, CA, United States; 2Radiology, Mount Sinai School of Medicine, New York, NY, United States; 3Radiology, University of Miami, Miami, FL, United States

MR spectroscopic imaging with localization schemes using conventional RF pulses suffer from B1 inhomogeneity and chemical shift localization error due to bandwidth limitations. Adiabatic refocusing RF pulses have been introduced to overcome the B1 inhomogeneity. However, conventional hyperbolic secant adiabatic refocusing pulses are limited by long pulse-width, prohibiting acquisition with short TE. Here, we present a localization scheme using adiabatic SLR refocusing pulses with broad bandwidth and short pulse-width. This localization scheme was incorporated into a volumetric MRSI sequence with echo planar readout. In vivo study showed high quality spectra and metabolite maps were obtained throughout the brain.

Abstract PDF Presentation Video

Keywords

acceptable accrued achieve acquisition addition adhering adiabatic allowed alteration alternatives automatically bandwidth brain broad care chemical chess choline clinical clinically compromise coupling datasets desired detect developed diagram dimensional distribution double duration efficient encoding energy error especially exacerbated excitation fast feasibility feasible fields final foundation frequency generated good health healthy hyperbolic identical implemented in vivo inaccuracy included incorporated inhomogeneity insensitive interleaved introduces inversion limitations lipid localization long loss magnitude male measured medicine metabolism metabolite metabolites midas minimize minimizing minute mount package pair parallel peak phantom planar plus processed profile proposed pulse pulses quadratic quality quantification radiology readout reasonable recovery reduction refocus refocusing representative required resolution sampling scanner scheme schemes school secant sheriff short shorten slab slice spatial spectra spectral spectroscopic spin subject successfully suffer suppression throughout tissue uniform volumetric water waveforms whole width widths year