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Abstract #3927

Hyperpolarization of Biologically Relevant Compounds Which Are Important in the GABA Metabolism

Markus Plaumann1, Ute Bommerich2, Thomas Trantzschel1, Denise Lego2, Sonja Dillenberger3, Joachim Bargon4, Gerd Buntkowsky3, Johannes Bernarding5

1Department of Biometry and Medical Informatics, Otto-von-Guericke-University Magdeburg, Magdeburg, Saxony-Anhalt, Germany; 2Special Lab Non-Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Saxony-Anhalt, Germany; 3Eduard-Zintl-Institute for Inorganic Chemistry, Technical University Darmstadt, Darmstadt, Hesse, Germany; 4Inst. of Physical and Theoretical Chemistry, University Bonn, Bonn, North Rhine-Westphalia, Germany; 5Department of Biometry and Medical Informatics, Otto von Guericke University, Magdeburg, Saxony-Anhalt, Germany

GABA is one of the most important inhibitory neurotransmitter in the central nervous system. Knowledge of changes in the GABA metabolism can help to understand different disease pattern. Therefore, the ParaHydrogen Induced Polarisation can be used to enhance signals for MR studies. In this contribution we described a new method to hydrogenate unsaturated organic amines in aqueous solution and present first spectra of hyperpolarized vigabatrin, allylglycine and GABA. All spectra were detected at 7 T. This new approach opens the way to hyperpolarize further biologically important molecules which were inaccessible to PHIP until now, like amino acids and peptides.

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Keywords

acid acids activity amines amino aqueous benzene biochemical biological biologically biometry bowers brain catalyst catalysts catalytic central chemistry compounds conditions demands depend described desired detected determined directly disease enhance enhancement enhancements enriched examinations example excitation experiment free furthermore generate glutamate help homogeneous hydrate hydrogenate hydrogenation important improved inaccessible induced informatics inhibit inhibitor inhibitory inorganic inst institute interact invasive investigations knowledge like medical metabolism molecule molecules multitude necessary nervous neurobiology neurotransmitter neutralization noise north opens optimization optimum organic pattern peptides phenyl phys physical play polarized precursor presence protecting prove pulse reaction realized relevant reporter rhodium role salt selected simply soluble solution special spectra spectrometer spectrum strategy subsequent substances substrate successful system target technical theoretical thermal titration trans transfer understand unprotected unsaturated vented water