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Abstract #3880

MRI Pulse Sequence Optimization for Molecular Imaging of the Brain Aneurysm Wall

Imramsjah M.J. van der Bom1, Matthew J. Gounis1, Shaokuan Zheng2, Juyu Chueh1, Anna Luisa Khn1, Alexei A. Bogdanov3

1Radiology/NECStR, University of Massachusetts Medical School, Worcester, MA, United States; 2Radiology/AMRIC, University of Massachusetts Medical School, Worcester, MA, United States; 3Radiology/Nuclear Medicine, University of Massachusetts Medical School, Worcester, MA, United States

To investigate the role of unruptured aneurysm wall inflammation and propensity for rupture, imaging parameters of a motion-sensitized driven-equilibrium black-blood sequence were optimized to suppress signal caused by slow non-linear blood flow within aneurysms while preserving CNR from surrounding tissue. Parameter optimization was performed using a silicone vascular replica and a rabbit aneurysm model. The optimized sequence was used to investigate signal enhancement of inflamed aneurysm walls in rabbits using a MPO-specific contrast agent. Blood signal within the aneurysms was sufficiently suppressed in all rabbits and a significant increase of SNR was observed in the inflamed aneurysms compared to controls.

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Keywords

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