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Abstract #3868

in vivo Magnetic Resonance Tracking of Endothelial Progenitor Cells Trafficking to Sites of Hepatoma Angiogenesis

Xiao Li Mai1, Hai Jian Fan2, Bing Han3, bin zhu3

1radiology, Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School, nanjing, jiangsu, China; 2Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; 3Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China

Tumors must establish new vascular network to promote growth and metastasis. The dependency of tumors on angiogenesis provides a rationale for anti-angiogenesis therapy of cancer targeted at shutting down the tumor blood-supply. Endothelial progenitor cells (EPCs) are precursors to vascular endothelial cells originating from the bone marrow, which have the ability to form endothelial colonies in vitro, may integrate into the neovasculature of tumors and could promote tumor angiogenesis.EPCs have been detected in the circulation of lymphoma-bearing mice and patients with cancer.

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