Meeting Banner
Abstract #3862

in vivo Magnetic Resonance Imaging of Activity-Dependent Neural Progenitor Cell Migration

Nikorn Pothayee1, Diana Cummings2, Leonardo Belluscio2, Alan P. Koretsky1

1Laboratory of Functional and Molecular Imaging, NINDS/NIH, Bethesda, MD, United States; 2Developmental Neural Plasticity Section, NINDS/NIH, Bethesda, MD, United States

Neural progenitor cells (NPCs) are produced throughout life by neural stem cells in the subventricular zone (SVZ). NPCs migrate from the SVZ through the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into various types of interneurons. Herein, we use cellular MRI to investigate potential role of olfactory sensory input on the rate and pattern of NPC migration.

Abstract PDF Presentation Video

Keywords

achieving activity affect although animal animals arrows audience axial bandwidth bangs brain brains built bulb caudal cell cells cellular coil control coordinates coronal currently custom dark declining decrease dependent deprivation detectable detected developmental diameter discussed distance distribution early efficient electronics endogenous england expected extent fates fields fishers functional good gradient growing horizontal hour hours in vivo indicate injected injection injections input integrated investigate label labeling laboratories laboratory lateral local loss magnet marked matrix measuring medial migrate migrating migration model modest modulating molecular monitoring natal neural neurons nostril observation occluded occlusion olfactory optimum oxford period plasticity post potential precursor previously process progenitor promote question rats reached reasonable receive recent recovery reduction replenish researchers resolution respectively revealed reversible section sensory serial session shim shrinkage side sites situ slower solution speed spot stem subjected supports suppress surface system target therapies thought tracking transmit travel turnover unclear unilateral ventral ventricle ventricles views volume week weeks whether zone