Meeting Banner
Abstract #3691

Alterations of Temporal and Prefrontal White Matter in Adult Macaques with Neonatal Hippocampal Lesion

Yuguang Meng1, Longchuan Li2, Xiaoping P. Hu2, Jocelyne Bachevalier3, Christa Payne3, Xiaodong Zhang1, 4

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 2Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; 3Yerkes National Primate Research Center and Department of Psychology, Emory University, Atlanta, GA, United States; 4Division of Neuropharmacology and Neurologic Disease, Emory University, Atlanta, GA, United States

A recent diffusion tensor imaging (DTI) study demonstrated that excitotoxic hippocampal lesions in adult macaques alter white matter tracts of the temporal and frontal lobes. In the present study, DTI was used to examine whether similar changes will also be found in adult macaque monkeys with similar selective hippocampal lesions done in infancy. Significant diffusivity alterations were found in the white matter of the temporal stem and ventromedial prefrontal cortex which is involved in memory consolidation and working memory retrieval.

Abstract PDF Presentation Video

Keywords

acquisition addition adult adulthood alter alterations altered animals audience axial bilaterally biomedical bottom brain childhood chimpanzee collected color complete connectivity considered consistent consolidation contrast contributions control correlation correlations correspondent cortex currently damage days decreased development diffusion diffusivity disease division dual early engineering especially evidence examine finding frontal funded gradient grant green handedness harmful hemisphere hemispheres human impaired impairment impairs indicated induced infancy infrastructure inputs insult intent interactions interestingly involved judgment lack lesion lesions lobes macaque macaques maintenance maps maturation measured measures memory monitoring monkeys months national neonatal neuron notion office ontogeny operated oxford parietal persistent physicists population positively post predicted primate processed processes programs project projection psychiatrists psychology radial received recent registered related relation reported resolution resources retrieval reversal rhesus role scanner scripts selective sham significantly skeleton spatial stage statistically stem subject system systems target technology template temporal tensor toolbox tracts troglodytes univariate variables volume volumes weighed whether white years young