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Abstract #3682

MRI of Neuronal Recovery After Methamphetamine Treatment of Traumatic Brain Injure in Rats

Guangliang Ding1, Michael Chopp1, 2, David J. Poulsen3, Lian Li1, Changsheng Qu4, Qingjiang Li1, Siamak P. Nejad-Davarani1, John Budaj1, 5, Hongtao Wu4, Asim Mahmood4, Quan Jiang1

1Neurology, Henry Ford Hospital, Detroit, MI, United States; 2Physics, Oakland University, Rochester, MI, United States; 3Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, United States; 4Neurosurgery, Henry Ford Hospital, Detroit, MI, United States; 5Biomedical Engineering, Oakland University, Rochester, MI, United States

Traumatic brain injury (TBI) is an important public health problem in Western countries. There is an urgent need to develop a novel approach for the treatment of TBI. With a CCI model of TBI in young Wistar rats, methamphetamine treatment of TBI significantly improved white matter reorganization at 5 to 6 weeks after TBI, compared with saline treatment, based on the MRI FA measurements. And significant correlation was detected between the FA and histological BLFB measurements. It suggested that the the improved white matter may contribute to the functional recovery after TBI in rat.

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