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Abstract #3659

Diffusion Tensor Markers of the Neurobiology of Cocaine Addiction

Khader M. Hasan1, MA Liangsuo2, Larry A. Kramer1, Scott D. Lane2, Joel S. Steinberg2, Ponnada A. Narayana1, Gerry F. Moeller2

1Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States; 2Psychiatry and Behavioral Sciences, University of Texas Health Science Center at, Houston, TX, United States

In this work we applied atlas-based methods to identify the macro and microstructural correlates of cocaine effects by incorporating white matter (WM) connections in addition to the limbic-thalamic-striatal-cortical regions as previously reported. Our study indicates that GM mean diffusivity of the cingulate cortex and thalamus may serve as early markers that could precede subsequent long term effects of cocaine on WM pathways.

Keywords

abuse according activation addiction addition ages alterations analyze anterior application assurance assure atlas axial brain cellular chronically clinical cocaine cohorts collinear comparable complicated connections consistent constriction control controls corpus correlates cortex cortical covering criteria decreased deep dependence dependent dependents described diagnostic diffusion diffusivity dopamine drug drugs elevated elevation entire expected females findings fractional frontal functional generalized global gray health healthy hinting history identification identifying included inclusion incorporating indicates insular integrity interventions journal lane lateral limbic linear lobar longer macro many maps markers measure measured neurologically neuronal neurotransmitters normalized patients pave percentages plots posterior potential precede predicted previous previously processing psychiatry quantitative radial reduced reflect regional regression reported representative role scanned scatter science sciences segmentation segmented sensitivity sensitized serially serve shot significantly slice slices station statistically stimulants studies subject subjects subsequent temporal tensor term thalamus therapeutic therapy tissue towards trends underway users utilized valid variance ventricular volume volumes white whole years zones