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Abstract #3654

Microstructural Characterization of Unidentified Bright Objects in Neurofibromatosis Type 1

Thibo Billiet1, Louise Emsell1, Felice D'Arco2, Sabine Deprez1, Judith Verhoeven1, Ellen Plasschaert3, Ronald Peeters1, Eric Legius3, Stefan Sunaert1

1Radiology, KULeuven, Leuven, Belgium; 2Radiology, University Federico II of Naples, Naples, Italy; 3Human Genetics, UZLeuven, Leuven, Belgium

"unidentified bright objects" are brain lesions occurring in neurofibromatosis type 1. They are related to learning disabilities. Nevertheless knowledge about their exact nature is limited. Using relaxometry and diffusion measures a detailed description of microstructure can now be obtained.

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Keywords

alterations altered although anisotropy applied around assesses axial biomedicine breakdown bright broadening brought calculation characterization compartments confirmed correlate debris decrease decreased difficulties diffusion diffusional diffusivity disorder distribution drawn edema elevated exact existence expression extracellular find flair formation fraction fractional genetic genetics geometric gradient human hypothesis in vivo indicating indicators intra known kurtosis learning lesions making materials nature objects orange paired patients peak peaks possibly previously protein radial radiology ranks reduced relevant respectively scanned scanner scores sheath signed sites space statistical strengths table toolbox type unidentified vacuolization visible water width yellow