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Abstract #3595

Impaired Small-World Efficiency in Structural Networks in Pediatric Bipolar Disorder

Minjie Wu1, Alexander Kmicikewycz1, Shaolin Yang1, Lisa Lu1, 2, Donatello Arienzo1, Mani Pavuluri1

1Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Psychology, Roosevelt University , Chicago, IL, United States

In the current study, graph theoretic analyses was applied to diffusion weighted data to explore the topological efficiency of structural networks in pediatric bipolar disorder (PBD). Significantly decreased small-worldness in PBD was observed, which may reflect decreased efficiency in information transfer, and may contribute to the affective and cognitive dysfunction in PBD.

Keywords

abnormalities affective analyses anisotropy applied approved architecture assent axial balanced bipolar board brain bravo care characterize cognitive coil complex computed connectivity consent consistently contribute controls correction cortical cost cross cyclical decreased deep degree density depression diffusion disorder disorders dysfunction eddy effectiveness efficiency electric episodes evaluates examined explore facilitates fact females fiber fibers focal fractional general generate global gradient graph graphs head health healthy hospital hundred illness impaired individual informed institutional integration known least local mania mapped matched materials matrix medium model mood motion network networks node optimally parent participants participated patients pediatric preprocessed processing psychiatry psychology quadrature quantitatively reflect represented review rotation scanned scanner sectional significantly slice slices software space sparse specialization start structural subject subjects superficial theoretic theory threshold toolkit topological topology tracking tracts transfer white world yang years