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Abstract #3589

Relationships Between Metabolite Concentrations and Working Memory Performance in Patients with Bipolar Disorder and Schizophrenia

Wen-Jang Chu1, 2, Mathew Norris, 23, Tracie Northern3, Judd Storrs2, David E. Fleck, 23, Elizabeth M. Fugate1, 2, Jing-Huei Lee, 23, Caleb M. Adler, 23, Melissa P. DelBello3, Henry Nasrallah3, Stephen M. Strakowski, 23

1Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States; 2Center for Imaging Research, Univ. of Cincinnati, Cincinnati, OH, United States; 3Psychiatry and Behavioral Neuroscience, Univ. of Cincinnati, Cincinnati, OH, United States

This 4-Tesal study investigated the relationships between regional metabolite concentrations and the accuracy of N-back working memory test in healthy subjects and patients with bipolar disorder and schizophrenia.

Keywords

abnormalities accuracy acquisition activation analyzed anterior article attentional audience availability axis back became behavioral biometrics bipolar brain child choline clinical coefficients comprised concentration concentrations condition confirm consented contribute controlled correlations cortex criteria decreased deficits development diagnoses difficulty disorder disorders dysfunction edition examined features find findings five fleck focus general gray guiding healthy henry highly hypothesized identified immediately in vivo inclusion increasing indeed indicates instead institute interview likely limited linear long loss manic meet memory metabolite methodologically might moreover negative neuropathology northern pairwise participants patient patients performance planar positioning positive preplanned press procedures prominent proposed psychiatric psychiatrists psychiatry psychology psychosis psychotic rating real recent reconstructed regional regression related relationships required researchers revealed review role scale scanner schizophrenia schizophrenic score sensitive separately seven severity spectra spectroscopy stronger structured studies subtle suggest summarized syndrome table target thereafter thirteen tissue underperformed univ unlikely verified young