Major Depression Impairs Biophysical Integrity of Brain Beyond Normal Aging Revealed by Magnetization Transfer Imaging

Keywords

abnormalities accelerate accompanied addition additional affect aging alone analyses analyzed anterior arch assessed atrophy axial beyond bilateral biophysical brain carried cell circuitry clinical clinics coil combination community component composition consent consistently control controlling controls correction correlated correlation correlations cortex covariance criteria decline declined decrease deep density depression depressive determined diagnosis differ dimensional dimensions disorder eight evaluation examined extensive findings focal formal fractional frequency frontal gender gradient gray head hemispheres human identified identify impairs implicated important include included increasing indicate integrity interview item laboratory lateral lobe local magnetization major materials medical membrane moment moreover needed negative negatively nucleus opposite partial patients placed planar possibly product protein psychiatric psychiatry pulse radiology ranging record recruited reflective related relatively relevant report represent required respective revealed review saturation scanner score scores sense severity shared significantly similarly slice slices smith spoiled statistical striking subjects subtle suggest supplementary survived tends thalamus tracts transfer twenty version volumetric white yang