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Abstract #3581

Atypically Increased Functional Connectivity in Young Adults with Borderline Personality Disorder

Jeong-Won Jeong1, 2, Jeffrey Kuentzel3, Carla D. Chugani4, Harry T. Chugani, 25, Diane C. Chugani, 26

1Pediatrics and Neurology, Wayne State University, Detroit, MI, United States; 2PET center, Children's Hospital of Michigan, Detroit, MI, United States; 3Psychology, Wayne State University, Detroit, MI, United States; 4Counseling and Psychological Services, Florida Gulf Coast University, Fort Myers, FL, United States; 5Pediatrics, Neurology, and Radiology, Wayne State University, Detroit, MI, United States; 6Pediatrics and Radiology, Wayne State University, Detroit, MI, United States

Borderline personality disorder (BPD) is a prevalent mental illness characterized by pervasive instability in emotion, interpersonal relationships, self-image, and behavior. Our previous functional MRI study reported atypically modulated Blood Oxygen Level Dependent signals in young adults with BPD, responding to emotionally congruent and incongruent music-face images. This study utilized topologic network analysis for resting state fMRI in order to investigate which brain networks are mostly affected (or functionally impaired) in young adults with BPD, which might provide an objective tool to quantitatively access atypically organized neural mechanism related to BPD phenotypes.

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Keywords

abandon accuracy acquisition adults affected altered anything atypically audience auditory behavior body bold borderline brain cerebellum characteristics children clinical coded communication connections connectivities connectivity consensus control controls correction correlation counseling covering cross densely dependent discrete discriminative disorder distribution disturbed efficiency emotion emotional emotionally evaluated every exhibited extremely eyes face filtered findings frame functional ganglia global grain healthy highest hypothesized impaired included individual inhibiting instability instructed integrate integration interconnected involved known leave limbic linear local loop machine magnitude matrix measure measures mechanism mental minute mode mostly multivariate music myers network networks neural neurology node nodes normalization olfactory organized others oxygen pairwise parallel participant patients pattern pediatrics perception personality phenotype power prevalent promise proportional providing quantifies radiology realignment regressed regulation relationships reported resting rigid scales segregation series services significantly slice spatial specificity sphere spontaneous steps subjects subsequent suggesting superior supplemented support system targeted third threshold trend utilized visual weighed whole women years young