Meeting Banner
Abstract #3558

A Framework for Causal Connectivity Analysis of fMRI in Patient Populations: An Application to Major Depression and Early Life Stress

Karthik Ramakrishnan Sreenivasan1, Merida M. Grant2, Gopikrishna Deshpande, 3

1 AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; 2Department of Psychiatry, University of Alabama School of Medicine, Birmingham, AL, United States; 3Department of Psychology, Auburn University, Auburn, AL, United States

The current study investigated effective connectivity in patients with Major depressive disorder (MDD). fMRI time series were deconvolved using a cubature Kalman filter to obtain underlying neural response which were input into a dynamic multivariate autoregressive model (dMVAR) to obtain effective connectivity metrics. The results showed that differential amygdala reactivity within MDD based on early life stress history was associated with failure of inhibition from medial or lateral PFC.

Keywords

abuse accurately activated among anterior application asked attention attenuated auburn autoregressive aversive button causal centralized characterized childhood clinical computer condition conflict congruent connectivity controls correlated correlation cortex decreased depression designed differential difficulty directional distinct dorsal dynamic early efficiency electrical emotion emotional engineering exaggerated examined exposed extracted faces failure filter findings flanker framework gender grant greater healthy history human hyper hypo identification identified identify illustrated incongruent inference influence inhibition input inputs investigated investigation journal lateral life limbic major matrices medial medicated medicine model models modulation multivariate negative neuronal neutral never normalizing originated outputs participants path paths patient patients perception phenotypes physical plot populated populations positive press procedure psychiatric psychiatry psychology psychophysics quickly reactivity represents respectively respond response responsive revealed roles samples scanner scatter schematic school scores selective separately series significantly similarly specifically statistical stimuli stress studies subtype supports target task translational trauma twenty unaffected underlying valence variant view volume whereas whether wood