Meeting Banner
Abstract #3556

Altered Thalamic Connectivity in Schizophrenia

Ali-Mohammad Golestani1, Dolores Malaspina2, Laura Miles1, Mariana Lazar1

1Radiology, Center for Biomedical Imaging, NYU Medical Center, New York, NY, United States; 2Psychiatry, NYU School of Medicine, New York, NY, United States

Previous research has reported alterations in the size, function, and connectivity of thalamus in schizophrenia. Most of the studies considered the thalamus as a homogenous region. Here, we used Resting-State fMRI connectivity to parcellate the thalamus into functionally distinct sub-regions. The connectivity maps of the identified sub-regions were compared between patients and controls . Thalamus was divided into two regions, dorsal and ventral, in both groups. In the control group, the dorsal region was negatively correlated to the cortical areas, whereas the ventral region was positively connected to them. Connectivity of both sub-regions appeared to be limited in patients. These differences in the thalamo-cortical connectivity were not detected when employing the whole thalamus as a seed.

Keywords

activation affected alteration altered although analyses anatomical annealing appear appears behavioral better binary biomedical block bottom brain brought close clustered columns common complex component components connect connected connectivity consequently considered control controls correction cortex cortical cortices describing detailed developed deviation diagonal discrepancies disorder displacement disrupted disruption distinct divided dorsal ensure evaluating explain extracting extraction fact field filtering frontal function functional generate generated gradient greater head healthy highlights homogeneous hypothesize identified identifying importance included inclusion inconsistent inhomogeneity kernel landmarks laura least limited lobe locally maps masks matched matrix mechanisms median medical medicine miles motion motor nervous nineteen optimization participants participating patients patterns plus positively power processing psychiatry radiology rather reduced regressors related reordered represents resting restricted rightmost rows scanned scanner schizophrenia school seed seeds segmentation several similarity simulated sixteen slice slices smoothing software solutions spatial squared statistically studies subject subjects syndromes system temporal thalamus trans understanding variance ventral visual volume white whole