Meeting Banner
Abstract #3554

Cerebrovascular Reactivity-Based Calibration of Presurgical Motor Activation Maps to Improve Detectability of the BOLD Signal in Patients with Perirolandic Brain Tumors

Domenico Zac1, 2, Sreenivasan R. Nadar1, Jorge Jovicich2, Jay J. Pillai1

1Division of Neuroradiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States; 2Center for Mind Brain Sciences, University of Trento, Mattarello, TN, Italy

The detectability of BOLD signal in brain tumor patients can be impaired by reduced cerebrovascular reactivity (CVR). In this study we propose to address this issue by introducing an algorithm that provides CVR based calibration of motor activation maps. This technique was applied in 5 patients with perirolandic brain tumors and demonstrated in each patient a statistically significant increase of activation in eloquent motor cortex surrounding the lesion.

Keywords

absent accounting activation alternating applied approved assess available away battery bilateral blocks board bold brain breath breathing calibrated calibration candidates cerebral clinical considered contrast corresponds cortex cortical created decreased decreases detect detectability discordance diseases division documented drawn elsewhere epochs equivalent example expected expressed extension false feasibility finger five flair foot functional generate generated generating gold grade hold holding impaired improve included individual institutional johns language last lesion literature long mapping maps margins materials medicine middle mind minimization minute minutes model motion motor movement negative normalization paced past patient patients percentage performance phenomenon pilot potential potentially preliminary proposed reactivity recent reduced referred regional repeated reported represents resection rest review scanner school sciences self shot spuriously statistically status stimulation structural studies subject subsequently subtracting surrounding table tapping task tasks threshold thresholded tissue tongue trio tumors uncoupling vertical volunteers whose wise