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Abstract #3453

Quantitative DCE-MRI as a Predictor of Acute Leukemia Response to Therapy

Mohan L. Jayatilake1, Aneela Afzal1, Xin Li1, Yiyi Chen2, William J. Woodward1, Tibor J. Kovacsovics3, William H. Fleming3, 4, Wei Huang1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Biostatistics, Oregon Health & Science University, Portland, OR, United States; 3Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States; 4Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, United States

Nine newly diagnosed acute myelogenous leukemia (AML) patients underwent DCE-MRI of vertebral body and iliac crest before standard chemotherapy. The pre-therapy bone marrow mean kep was found to be a good predictor of complete remission following therapy. DCE-MRI may be a useful noninvasive imaging method for non-solid tumor cancer studies.

Keywords

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