Meeting Banner
Abstract #3445

No Volumetric and Metabolic Differences in the Brain Between Severely Fatigued and Non-Fatigued Disease-Free Cancer Survivors

H. Prinsen1, H. W.M. van Laarhoven1, 2, G. Bleijenberg3, M. J. Zwarts4, M. van der Graaf5, 6, M. Rijpkema7, Arend Heerschap5

1Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Medical Oncology, Academic Medical Centre, University of Amsterdam, Amsterdam, Noord-Holland, Netherlands; 3Expert Centre for Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 4Epilepsy Centre Kempenhaeghe, Heeze, Noord-Brabant, Netherlands; 5Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 6Clinical Physics Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 7Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

Until now, little is known about (neuro)physiological factors determining postcancer fatigue, which is a frequently occurring problem, impairing quality of life. For non-cancer patients with chronic fatigue syndrome, certain characteristics of brain morphology and metabolism were already identified. We investigated whether these volumetric and metabolic traits are a reflection of fatigue in general and thus also be of importance for postcancer fatigue. However, the studied volumetric and metabolic parameters are not related to postcancer fatigue. This may suggest that, although postcancer fatigue and chronic fatigue syndrome show strong resemblances as a clinical syndrome, the underlying physiology is different.

Abstract PDF Presentation Video

Keywords

academic addresses already although analyzed anatomical assess assessed assigned behavior brain brooks cancer certain characteristics checklist choline chronic clinical clinically cognitive coil concentrations condition contrast controlled coronal cortex decrease defined determining disease earlier epilepsy establish evidence examine example excluded explain explore expressed fatigue fatigued free frequently general global gray head hypothesized impairing included individual intervention invalidating investigation known laboratory larger life little malignant markers matched measured medical medicine metabolic metabolite minimal module months morbidity morphology mostly noted nuclear nucleus occipital occurring oncology package participants past patient patients percentage period perpetuating physics physiological physiology position power problem pulse radiology randomized randomly recurrence reduced reducing reflection relevant reported resemblances resolution respectively scores segmentation segmenting severe severely severity significantly slice solid spectra spectroscopic spectroscopy spectrum strength strong structures studied studies suffered suggest survivors syndrome system table thalamus therapy toolbox transversal treatment trial trials tumor twice uncontrolled underlying volume volumes volumetric waiting white whole year