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Abstract #3437

Performance of Gd-EOB-DTPA MRI Criteria for Diagnosis of Pathologically Proven HCC: A Comparison with AASLD and Barcelona Criteria.

Anokh Pahwa1, Katrina Beckett2, Stephanie Channual2, Nelly Tan2, David Lu2, Steven Raman2

1Olive View-UCLA Medical Center, Sylmar, CA, United States; 2UCLA, Los Angeles, CA, United States

Hepatobiliary specific MR contrast is becoming more prevalent, and understanding its applicability with existing imaging criteria is essential for the noninvasive evaluation of the cirrhotic liver. The purpose was to determine the applicability of Gd-EOB-DTPA, an extracellular contrast agent, with and without hepatobiliary phase imaging in conjunction with established AASLD and Barcelona Criteria for imaging-based diagnosis of hepatocellular carcinoma (HCC). Hepatobiliary phase imaging when using Gd-EOB-DTPA increased sensitivity for the diagnosis of HCC when compared to using established criteria alone, with a small decrease in specificity, which supports a role for hepatobiliary specific contrast agents to improve diagnosis of HCC.

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Keywords

abdominal accuracy accurate acid addition agents alone appearance applicability approved arterial assist audience becoming biliary biopsy blinded capability carcinoma categorized characterization cirrhotic clarify clinical compliant comprehensively confirmed conjunction consecutive contrast criteria days decrease defined determine diagnosing diagnosis either enhanced enhancement essential established evaluation examine existing extracellular findings focal general helping improve improved lack lesion lesions liver maximizing medical meeting nodules noninvasive olive optimization part pathologically patients pattern percutaneous performance practice prevalent protocol proven radiologists resection respectively role sensitive sensitivities sensitivity specificities specificity support suspected target tree trial understanding uptake venous view washout