Monitoring PKM2 Status in Glioblastoma Using Hyperpolarized 13C MRS

Keywords

accordingly acid acidification acids acknowledgments activity aerobic alanine allowed amino assay assessed association beads bicarbonate blocks blot blue brain briefly buffer building cancer catalyzes cell cells central chemical circulated coding complex concentration confirmed consistent constant control controls conversion converts coupled courses cultured described detected drop dropped enhanced enzymatic enzyme enzymes equations every express expression facilitates fellowship final formation generated glucose green grown highlighted hour hydrate illustrates importantly indirectly injected injection insert intensities kinetic knockdown knocked lactate lead leading live loaded material measured mediating medium metabolic metabolism metastasis mind models modified modulation monitor monitored nature necessary neurological noise normalized oxidative peaks perfused perfusion physical plays plot polarizer polyethylene post previously prior probed processing production prove providing pseudo quantification questioned radiology role samples schematic science scrambled serve significantly software specifically spectra spore status studies substrate supplemented supplied surgery switch system therapeutic therapies transduction treatment tube tumor useful valve viability ward western whereas whether