Validation of Hyperpolarized 13C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor

Keywords

acid activity addresses aggressiveness applied architecture assayed benign biomedical biopsies cancer cell cells choline citrate clinical clinically companion compatible concentration concentrations conducted continuous contrast corp correlates culture cultured cultures decreases demonstrating derive derived described developed development disease dramatically emerged enrichment evidence exhibit expression extended facilitate flow flux fold foster fractional frozen future glucose glut glutamate guided histology hours human identification immortal impeded in vivo included incubated incubator injected injection instruments integrated investigate issues john labs lactate literature malignant markers mechanistic media median medium metabolic metabolism metabolites model modified necessary nelson novel oxford patient perfused polarization positive post preservation pressing previously primary probes processed produce profile progression proliferation prostate providing purchased radical radiology rapidly recapitulates recent relevant reprogramming rotator safety secs selection significantly situation slice slices snap software specimens spectra spectroscopy stability stable steady structure studies supplemented system taken therapeutics tissue tissues track translatable transporters treatment trial tumor unlabeled untreated utilized utilizing validation years