Meeting Banner
Abstract #3426

Is Higher Lactate Generation Rate an Indicator of Tumor Metastatic Risk?-A Pilot Study Using Hyperpolarized 13C-NMR

He N. Xu1, Stephen J. Kadlececk1, Harrilla Profka1, Ben Pullinger1, Jerry D. Glickson1, Rahim Rizi1, Lin Z. Li1

1University of Pennsylvania, Philadelphia, PA, United States

Increased glycolysis resulting in higher lactate production (the Warburg effect) has been demonstrated in tumor tissues in numerous studies including some that employed hyperpolarized 13C-NMR. High levels of hyperpolarized lactate were correlated with high tumor grades. In this study we aim to investigate if the difference in levels of hyperpolarized lactate reflects differences in tumor growth rate or tumor metastatic risk. We examined two breast tumor mouse models, the less metastatic but faster growing (MCF-7) and the more metastatic but slower growing (MDA-MB-231) tumors and quantitatively compared their metabolism using the hyperpolarized 13C-1-pyruvate NMR technique.

Abstract PDF Presentation Video

Keywords

administering alanine anesthetized answer apparent assumption audience benefit body bore breast cancer catalyzed cells challenges chance clear clinical coil collected completed conditions consistent constant constants contradicting conversion correlates correlation course courses curve customized dependence detect detection determination determine displays doped dual employed error every examined exhibited faster field fitting forward generation grade grades grading grant greatest growing growth heated histological home human indicate indicating indicator injection inoculated intensity jerry lack lactate larger localizing made maintained meeting metabolism metastatic mice million minutes models morris mouse necessarily nominal noninvasive nude numerous oxygen particularly period pilot positive positively potential practitioners preliminary presumably produce production program prostate pulse quality quantification quantify quantitative quantitatively question rapid reaction reflects related remains reported researchers reverse risk selective significantly site situ slice slower smaller spectra spectrometer studies subcutaneously sufficient suggests supply supported surface table tail target temperature threshold tissues tumor tumors tuned typical unpaired vein vertical volume weber whereas