Characterization of an Orthotopic Mouse Model Developed from Human Glioblastoma Spheres

Keywords

acid acquiring acquisition adjacent allowing animals appearance appeared arrow arrows assessed bearing became berger better body buffered cancer catheter cellular characterization clinical clinically clinics close complete confirm consisted containing context contiguous contrast days delineating depth derived developed developing development diagnostic disease dispose dose drug encountered enhanced enhancement equipped evaluated evolution examination exceptional expansion failure features female field findings gadolinium growth healing hemisphere heterogeneity heterogeneous histological human implantation important improved in vivo infiltrating infiltrative injected injection inside institute inter invasion irregular lesion longitudinal manually materials matrix mice mimic mimics minutes model models month months moribund mouse must necrotic needle normalized nucleus nude ones outline overall pathology pattern phosphate pixel pixels placebo post prior quantified randomized rapid rare remaining representative respectively response sacrificed saline scanner sequels sham significantly signs slice slices slower slowly specification spheres stabilizing strategies studies sufficient summing surgical survival terms therapeutic third trajectory treated treatment tumor tumors untreated useful ventricles volume volumes