Meeting Banner
Abstract #3407

The Comparison of Arterial Spin Labeling Perfusion MRI and DCE-MRI in Bone Metastasis from Prostate Cancer

Wenchao Cai1, Feiyu Li1, Jing Wang2, Huarui Du2, Jue Zhang2, 3, Xiaoying Wang1, 3, Xuexiang Jiang1

1Department of Radiology, Peking University First Hospital, Beijing, China; 2Peking University, Department of Biomedical Engineering, Beijing, China; 3Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

Pulsed arterial spin labeling (PASL) MRI is a non-invasive imaging tool capable of quantitatively measuring the microvascular perfusion characteristics of tissue through tagging arterial water to obtain the blood flow (BF) map. Angiogenesis plays a vital role in the metastatic process of prostate cancer, and bone metastasis lesion is hypervascular certificated by dynamic contrast-enhanced (DCE) MRI and histopathologic findings. We applied the PASL technique to detect bone metastasis from prostate cancer and to compare the differences BF values between the metastatic lesions and normal bone in the pelvis. The mean BFs determined by ASL MRI with different TI in the bone metastasis from prostate cancer were significantly higher than those in noncancerous bone regions (P<0.05, Paired T-test) Significant positive correlations between BF value and Ktrans, Kep were observed in all four TI , respectively. ASL is a new non-invasive imaging method with potency in detecting and monitoring therapy efficacy of bone metastasis from prostate cancer.

Abstract PDF Presentation Video

Keywords

academy administered advanced antigen applied approved arrow arterial audience biomedical blood body bolus bone cancer capable certificated characteristics china clinical clinicians committee computed conducted confirmed consistent control correlated correlation correlations curve detect detecting detection determined dynamic effective efficacy eight elevated engineering equal ethics explore fair femur findings flow flush gradient head hospital indicates injector interdisciplinary invasive inversion kinetic labeling lesion lesions local mappings measuring median metastasis metastatic monitoring neck noncancerous paired pathologically pathology patients pelvis perfusion placed plays positive post potency power previous process procession property prostate protocol proved pubic pulse pulsed quantitatively radiologists radiology recruited resolution respectively role saline scanner serum significantly spin spoiled straight studies table tagging target technologists temporal therapy tissue tool tracking vital volume water years