Meeting Banner
Abstract #3309

Assessing the Effect of Midazolam on the Brain Functional Connectivity Using Graph Analysis

Hazim Omar1, Theodore Kypraios2, Dorothee P. Auer1, Naranjargal Dashdorj1

1Radiological and Imaging Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2School of Mathematical Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

Resting state fMRI had been reported to have small-world architecture in the brain. We investigate the effect of hypnotic and sedative drug, midazolam administration on the functional brain network by using graph analysis and found a small-world network characteristic in both condition pre and post midazolam administration with a significant increase in clustering coefficient which indicate synchronized cliquishness functional network. There is also significant increase in local efficiency which reflects the increase in ability of a network in transmitting the information. This evidence suggests graph theory analysis can provide an insight in exploring the effect in functional brain connectivity.

Keywords

achieved activations addition administration aging allows altered anatomical approved architecture association attention attribute attributes body brain calculating characteristic characteristics cliquishness clustering coefficient committee complex component components conditions confers confirmed connections connectivity consciousness corrected correction correlation cortical cost derived detect dimensions disease done drug efficiency energy enhanced environment ethics evidence filtering finding flirt flow functional functions global graph head healthy highly honey human hypnotic impairment individual induced informed inspected integrated integration intervention investigate involved kingdom known lasted length local locally long loss macroscopic male mathematical matrices matrix measure memory model motion needed network networks nodes noise optimal outside pass path physiological plot post preprocessed previously properties radiological reduced reflection registration resource resting scale scanned scanner school sciences scored sedation sedative selected series signature slices smoothing software spatial stimulus structural studies subject subjects suggests synchronized system theoretical theory threshold thresholded transient twelve undergoing underpin upon validated visually volunteers watts whether white widely world