Learnings and Recommendations for Performing Multi-Center Clinical Drug Trials with Resting State Functional MRI in Alzheimer Patient Population: Data Processing Pipelines and Functional Connectivity Metrics

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acknowledgments acquisition anatomical assessed assessments assumption automatic averaging better brain burden characterized class clinical coefficient coefficients cohorts comments comparable component computed confidence connectivity consecutive context corrected correction correlation cortex curves cutoff datasets degree derived detect detecting differentiate differentiates dimensionality disease distinguish drug enhanced ensuing equivalent estimation exploratory extracted field filtered finally fitting functional functions general global goodness house implications include included independent infer interval intervals intra investigated larger like linear local made magnets major make manufacturer manufacturers matched materials measured melodic metrics minimal mode model motion need needed network nonlinear note novel nuisance optimizations oxford patient patients performance pipeline pipelines population posterior potential power processed processing psychiatry quantitatively recommendations registered registration regress regressed regressing reliable remaining render reproducibility resolution resting retest sample scanned score seed sets seven significance significantly site sites spatially strength stronger studied studies subject subsequently successfully suggestions table temporal temporally thank therapeutic together trial trials typical variables variation